Inter need three points against FC Sheriff Tiraspol at San Siro and Simone Inzaghi seems set to start with Lautaro Martinez and Edin Dzeko up front on Tuesday.
The match at the Giuseppe Meazza kicks off at 20.00 UK time.
Inzaghi’s men are looking for their first goal in the competition, after losing against Real Madrid in the first home game and then drawing 0-0 with Shakhtar Donetsk in Ukraine.
Sheriff arrive in the fashion capital with six points from the first two games and Inzaghi stressed the match will be ‘fundamental’ for the path in Europe.
Milan Skriniar, who is expected to start in defence, wants a clean sheet after conceding in seven Serie A games on the bounce.
Matteo Darmian and Denzel Dumfries are fighting for a place at right, while Matias Vecino and Arturo Vidal are battling for a place in the middle.
Lautaro Martinez and Edin Dzeko should start up front for the Nerazzurri, while Sheriff have to key players absent for the trip to Milan.
Goalkeeper Giorgos Athanasiadis from Greece must be replaced by Dumitru Celeadnic, while Uzbek Jasurbek Yaxshiboyev will be missed in attack at San Siro.
Probable line-ups: Inter vs. FC Sheriff
Inter (3-5-2): Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Vecino, Perisic; Lautaro, Dzeko
FC Sheriff (4-2-3-1): Celeadnic; Costanza, Arboleda, Dulanto, Cristiano; Addo, Thill; A. Traore, Kolovos, Castaneda; Bruno Souza