Marcus Thuram and Lautaro Martinez start again in the Inter attack against strugglers Venezia, but Nicolò Barella is expected to go to the bench.
It kicks off at 20:45 CET (18:45 GMT) at the Stadio Meazza in San Siro, Milan.
The Nerazzurri beat Empoli 3-0 away on Wednesday, while Venezia secured a comeback win over regional rivals Udinese.
Alessandro Bastoni and Barella are expected to rest for the Nerazzurri this evening, making room for Yann Bisseck and Piotr Zielinski. Davide Frattesi, scorer of a brace against Empoli, will start again in the middle of the park.
No rotations in attack where Thuram and Lautaro Martinez will start again for the defending Serie A champions.
Denzel Dumfries is favourite over Matteo Darmian as a right midfielder.
Inter loanee Filip Stankovic is expected to start between the sticks for Venezia and the same is true of Gaetano Oristanio in attack.
Bjarki Bjarkason is unavailable for the Lagunari, while Carlos Augusto and Kristjan Asllani are out of action for Inter.
Inter vs Venezia – where to watch on TV
The Stadio Meazza clash is available on TNT Sports 1 in the UK and can also be streamed on OneFootball. Fans in the USA can stream it live on Paramount+. BeIN Sports and beIN SPORTS CONNECT show the game live in Australia and New Zealand.
Inter vs Venezia – probable line-ups
Inter (3-5-2): Sommer; Bisseck, De Vrij, Pavard; Dumfries, Frattesi, Zielinski, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez.
Venezia (3-5-2): Stankovic; Altare, Svoboda. Idzses; Zampano, Nicolussi Caviglia, Duncan, Busio, Haps; Oristanio, Pohjanpalo.