Ciro Immobile and Lorenzo Insigne have both left the Italy camp ahead of tomorrow’s World Cup qualifier against Lithuania, while Nicolò Zaniolo is also in doubt.
It kicks off on Wednesday at 19.45 UK time (18.45 GMT) at the Mapei Stadium in Reggio-Emilia.
It has been announced that Insigne and Immobile have both been released early from international duty.
Napoli captain Insigne was given permission due to personal reasons, while Lazio forward Immobile was ruled out by a muscular injury.
It is bad news for coach Roberto Mancini, especially as Zaniolo also skipped today’s training session after a bruise to the thigh and is in doubt to feature tomorrow.
Marco Verratti and Lorenzo Pellegrini had left the training camp yesterday with minor injuries.
Italy were held to back-to-back draws in the World Cup qualifying group, 1-1 by Bulgaria and 0-0 in Switzerland.
We could now see Giacomo Raspadori get his first senior Italy start at the centre of the trident attack, flanked by Juventus pair Federico Chiesa and Federico Bernardeschi.
Matteo Pessina should step in for Nicolò Barella and Stefano Sensi allow Jorginho some rest.
Davide Calabria could be thrown straight in at right-back, with Cristiano Biraghi on the left.
Probable line-up
Italy (4-3-3): Donnarumma; Calabria, Acerbi, Bastoni, Biraghi; Pessina, Sensi, Locatelli; Chiesa, Raspadori, Bernardeschi