Spain dominated possession and forced a save, but Emerson Palmieri clipped the crossbar for Italy on the stroke of half-time as the UEFA EURO 2020 semi-final remains goalless.
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The winners of this showdown go on to meet England or Denmark in the Final, also at Wembley Stadium, on Sunday.
Both sides lost important players to injury, Leonardo Spinazzola and Pablo Sarabia, so Emerson Palmieri and Dani Olmo stepped in, but the big surprise was Alvaro Morata and Gerard Moreno dropped in favour of False 9 Dani Olmo.
Nicolò Barella’s lob thumped the inside of the far post within four minutes, but he had just wandered offside. Oyarzabal’s first touch let him down when clear on goal, allowing Emerson to intercept, then Ciro Immobile and Barella were unable to make the most of an Unai Simon error.
Gianluigi Donnarumma had to be alert after Dani Olmo won a lucky ricochet off Leonardo Bonucci, as Spain’s False 9 approach seemed to take Italy by surprise.
Emerson almost scored on the stroke of half-time, as he was set up by Lorenzo Insigne’s reverse pass, but the shot was deflected off Cesar Azpilicueta to clip the crossbar.
Italy 0-0 Spain (Half-Time)
Italy: Donnarumma; Di Lorenzo, Bonucci, Chiellini, Emerson Palmieri; Barella, Jorginho, Verratti; Chiesa, Immobile, Insigne
Spain: Unai Simon; Azpilicueta, Eric Garcia, Laporte, Jordi Alba; Koke, Busquets, Pedri; Ferran Torres, Oyarzabal, Dani Olmo
Ref: Brych (GER)