Genoa are without Andrea Favilli, Nicolas Spolli, Federico Marchetti and suspended Domenico Criscito against Inter.
It kicks off on Saturday at 14.00 GMT, click here for a match preview.
The Grifone must reshuffle their defence, as Criscito sits out a one-match ban.
Spolli, Favilli and goalkeeper Marchetti remain on the treatment table.
Genoa are without Andrea Favilli, Nicolas Spolli, Federico Marchetti and suspended Domenico Criscito against Inter.
It kicks off on Saturday at 14.00 GMT, click here for a match preview.
The Grifone must reshuffle their defence, as Criscito sits out a one-match ban.
Spolli, Favilli and goalkeeper Marchetti remain on the treatment table.
That means Ionut Radu is likely to stay in goal against his old club, despite his last-minute howler in the midweek 2-1 defeat to Milan.
There are several former Inter players in the side, including Lisandro Lopez, Goran Pandev and Daniel Bessa.
Genoa squad for Inter: Gunter, Lisandro Lopez, Romulo, Piatek, Lapadula, Kouamé, Biraschi, Mazzitelli, Romero, Rolon, Pandev, Lazovic, Russo, Bessa, Vodisek, Dalmonte, Sandro, Pereira, Lakicevic, Omeonga, Veloso, Medeiros, Zukanovic, Hiljemark, Radu