Roma were held to a 0-0 draw in Faro, despite Sevilla seeing Nemanja Gudelj sent off after 65 minutes, as Jose Mourinho rotated his squad.
The pre-season tour continues in Portugal, with the coach making numerous changes from the side that drew 1-1 with FC Porto in an ill-tempered game.
Daniel Fuzato had to make a tricky save within three minutes, palming a Lucas Ocampos volley out from under the bar. Soon after, a horrible Ebrima Darboe back-pass was intercepted, but Oscar Rodriguez ballooned over the bar with only the goalkeeper to beat.
Sevilla made a mistake too in their passing and Henrikh Mkhitaryan pounced, forcing a fingertip save from Marko Dmitrovic.
Fuzato used his legs to parry from Youssef En-Nesyri at the near post, while Stephan El Shaarawy just failed to get on the end of an inspired Mkhitaryan slide-rule pass.
A Carles Perez free kick went around the wall and forced Dmitrovic into a tricky save, and on the resulting corner, Marash Kumbulla’s header skimmed the crossbar.
El Shaarawy forced a save after combining with Lorenzo Pellegrini and En-Nesyri missed a sitter after the restart, failing to make the most of a lucky ricochet.
Sevilla went down to 10 men on 66 minutes, as Nemanja Gudelj was already on a yellow card when he rugby-tackled Nicolò Zaniolo to the ground.
Amadou Diawara blasted just wide and Zaniolo had squirmed was cleanly tackled by Oscar Rodriguez when clear on goal, although Edin Dzeko was offside on the assist anyway.
Despite being a man down, Sevilla nearly won it in the final minutes, Rui Patricio fingertipping a Romero attempt over the bar.
Roma 0-0 Sevilla
Roma: Fuzato (Rui Patricio 46); Reynolds (Karsdorp 46), Ibanez (Smalling 73), Kumbulla, Calafiori (Mancini 60); Bove, Darboe (Diawara 46); Perez (Zalewski 73), Mkhitaryan (Pellegrini 46), El Shaarawy (Zaniolo 60); Mayoral (Dzeko 60)
Sevilla: Dmitrovic; Jesus Navas, Rekik, Fernando (Ortiz 46), Jose Angel; Gudelj, Rakitic, Oscar Rodriguez (Johansson 91); Suso (Juanlu 87), En-Nesyri (Romero 70), Ocampos (Perez 70)
Sent off: Gudelj 66 (S)