Inter make changes with Alexis Sanchez and Roberto Gagliardini coming in for the trip to Empoli, as Andrea Pinamonti wants to impress his parent club.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Castellani.
Simone Inzaghi is sitting out a touchline ban after his furious reaction to the late Juventus penalty in last week’s 1-1 draw.
He rotates his squad for the midweek round, bringing in Alexis Sanchez, Gagliardini and Danilo D’Ambrosio to rest Edin Dzeko, Hakan Calhanoglu and Milan Skriniar.
Empoli’s star man is Inter youth product Pinamonti, who is eager to impress his parent club, supported by Nedim Bajrami and Patrick Cutrone.
Federico Di Francesco and Simone Romagnoli are out of action.
Empoli:Vicario; Stojanovic, Ismajli, Luperto, Parisi; Zurkowski, Ricci, Bandinelli; Bajrami; Cutrone, Pinamonti
Inter:Handanovic; D’Ambrosio, De Vrij, Bastoni; Darmian, Barella, Brozovic, Gagliardini, Dimarco; Alexis Sanchez, Lautaro Martinez