Milan rotate the squad, giving Divock Origi his first start for the club with Ante Rebic, as on-form Monza visit San Siro under former Rossoneri chief Silvio Berlusconi.
It kicks off at the Stadio Giuseppe Meazza at 17.00 UK time (16.00 GMT).
This is a very special match, the first time that Berlusconi and Adriano Galliani have faced their past, as after 31 years taking Milan to the top of world football, they started again bringing Monza from Serie C to the top flight.
Meanwhile, Stefano Pioli is distracted by the upcoming Champions League showdown with Dinamo Zagreb, along with an injury list that includes Mike Maignan, Davide Calabria, Alessandro Florenzi, Alexis Saelemaekers and Zlatan Ibrahimovic, while Ismael Bennacer can start despite struggling with flu symptoms.
Simon Kjaer and Charles De Ketelaere are back in the squad, but Rafael Leao and Olivier Giroud are rested in favour of Origi and Ante Rebic.
Monza have won four of their five games under coach Raffaele Palladino, eliminating Udinese from the Coppa Italia with a 3-2 thriller midweek.
Armando Izzo is injured and Nicolò Rovella suspended in midfield.
Milan: Tatarusanu; Dest, Kjaer, Tomori, Theo Hernandez; Pobega, Bennacer; Messias, Brahim Diaz, Rebic; Origi
Monza: Di Gregorio; Antov, Pablo Marì, Caldirola; Ciurria, Barberis, Sensi, Carlos Augusto; Pessina, Caprari; Mota Carvalho