Marcelo Brozovic has shaken off a muscular problem to start with Romelu Lukaku and Lautaro Martinez as they visit Serie B champions Lecce.
It kicks off at the Stadio Via del Mare at 19.45 UK time (18.45 GMT).
The Nerazzurri have struggled in pre-season, especially in defence, conceding far too many goals.
Brozovic was a major doubt for this game with a calf problem, but he has recovered to start in midfield, with only Danilo D’Ambrosio injured.
Lukaku makes his return to Serie A one year after leaving for Chelsea, reunited with Lautaro Martinez, while Robin Gosens takes over the left flank.
Lecce won the Serie B title last season, but go into this game with quite a few injuries to deal with.
Alessandro Tuia, Kastriot Dermaku, Daniel Samek, Kristoffer Askildsen, and John Bjorkengren are all dealing with fitness concerns.
It is raining very heavily in Lecce, which could make play tricky.
Lecce: Falcone; Gendrey, Cetin, Baschirotto, Gallo; Bistrovic, Hjulmand, Gonzalez; Strefezza, Ceesay, Di Francesco
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Darmian, Barella, Brozovic, Calhanoglu, Gosens; Lautaro Martinez, Lukaku