Italy start Giorgio Chiellini in his final international appearance with a completely revamped attack due to injuries in the Finalissima, while Argentina have Lionel Messi, Lautaro Martinez and Angel Di Maria.
It kicks off at Wembley Stadium in London at 19.45 UK time (18.45 GMT).
This is the third edition of the tournament between the reigning European Champions and the Copa America holders, with previous trophies won by France in 1985 and Argentina in 1993.
- Watch Italy vs. Argentina in the Finalissima and Germany and Hungary in the UEFA Nations League exclusively on Premier Sports for only £9.99 a month.
The Azzurri lifted the EURO 2020 trophy in this very stadium under a year ago, yet things have changed a great deal since then, failing to qualify for the World Cup and losing key players to injury.
Leo Messi is the star man, facing his PSG teammate Gianluigi Donnarumma.
Italy bench: Cragno, Spinazzola, Locatelli, Lazzari, Florenzi, Politano, Meret, Acerbi, Cristante, Scamacca, Pellegrini, Bastoni
Argentina: E Martinez; Molina, Romero, Otamendi, Tagliagico; De Paul, Rodriguez, Lo Celso; Messi, Lautaro Martinez, Di Maria
Argentina bench: Armani, Foyth, MacAllister, Pezzella, Acuña, Alvarez, Rulli, Palacios, N Gonzalez, Lisandro Martinez, Papu Gomez, Dybala
Ref: Maza Gomez (CHI)