Roma will open their Europa League campaign against Athletic Club on September 26 and visit Tottenham on November 28, while Lazio begin with Dynamo Kyiv on September 25.
As with the Champions League and Conference League, UEFA have transformed the formats of all their club tournaments for the 2024-25 season.
They will now play eight different opponents – four at home and four away – with all the results going into one giant league table.
It is somewhat confusingly called the Europa League League Phase.
Click here for all the fixtures and kick-off times from UEFA.
Europa League
Lazio fixtures
Dynamo Kyiv-Lazio, Sep 25
Lazio-Nice, Oct 3
Twente-Lazio, Oct 24
Lazio-Porto, Nov 7
Lazio-Ludogorets, Nov 28
Ajax-Lazio, Dec 12
Lazio-Real Sociedad, Jan 23
SC Braga-Lazio, Jan 30
Roma fixtures
Roma-Athletic Club, Sep 26
Elfsborg-Roma, Oct 3
Roma-Dynamo Kyiv, Oct 24
Union Saint-Gilloise-Roma, Nov 7
Tottenham-Roma, Nov 28
Roma-Braga, Dec 12
AZ Alkmaar-Roma, Jan 23
Roma-Eintracht Frankfurt, Jan 30