Atalanta look to Luis Muriel and Mario Pasalic for the Europa League quarter-final against Andre Silva’s RB Leipzig.
The first leg kicks off in Germany at 17.45 UK time (16.45 GMT).
La Dea dropped down into this tournament from the Champions League and eliminated Bayer Leverkusen in the play-offs, winning home and away.
Joakim Maehle, Rafael Toloi and Berat Djimsiti are injured, so Marten de Roon starts in the back three rather than teenager Giorgio Scalvini.
Duvan Zapata is on the bench ahead of schedule, but not yet able to start, so Muriel and Pasalic lead the way.
Leipzig are without Yussuf Poulsen and Amadou Haidara, but have plenty more star names, including Hungary international Dominik Szoboszlai, Dani Olmo, Emil Forsberg and ex-Milan striker Andre Silva.
The Germans are unbeaten since February 5, when they lost 3-2 at Bayern Munich, managing seven wins and three draws in all competition.
Both sides have a fairly similar 3-4-2-1 approach to their tactics.
RB Leipzig: Gulacsi; Gvardiol, Orban, Klostermann; Angelino, Kampl, Laimer, Henrichs; Dani Olmo; André Silva, Nkunku
RB Leipzig bench: Tschauner, Martinez, Simakan, Forsberg, Szoboszlai, Mukiele, Halstenberg, Raebiger, Novoa
Atalanta: Musso; De Roon, Demiral, Palomino; Hateboer, Koopmeiners, Freuler, Zappacosta; Pasalic, Pessina; Muriel
Atalanta bench: Rossi, Sportiello, Boga, Pezzella, Malinovskyi, Mihaila, Scalvini, Cittadini, Miranchuk, Duvan Zapata
Ref: Oliver (ENG)