Atalanta have Duvan Zapata, Jeremie Boga and Ruslan Malinovskyi leading the way against Andre Silva and Dani Olmo’s RB Leipzig in the Europa League quarter-final.
The first leg ended 1-1 in Germany and the decider kicks off in Bergamo at 17.45 UK time (16.45 GMT).
The away goals rule no longer applies in Europe this season, so whoever wins the match today goes through to the semi-final.
Berat Djimsiti and Remo Freuler have recovered after missing the weekend defeat to Sassuolo, but it is Hans Hateboer who starts in a four-man defence rather than Giorgio Scalvini.
The big news is upfront, where Gian Piero Gasperini goes all-out attack with Malinovskyi, Teun Koopmeiners and Boga supporting Duvan Zapata in what appears to be a 4-2-3-1 formation.
RB Leipzig are missing Amadou Haidara, but otherwise have a full squad at their disposal with Yussuf Poulsen returning.
Former Milan striker Andre Silva saw his penalty saved by Juan Musso in the first leg, but Davide Zappacosta scored an own goal almost immediately afterwards.
It was a high-octane match in Leipzig, with both teams rattling the woodwork twice.
Atalanta: Musso; Hateboer, Demiral, Palomino, Zappacosta; De Roon, Freuler; Malinovskyi, Koopmeiners, Boga; Duvan Zapata
Atalanta bench: Rossi, Sportiello, Muriel, Pezzella, Djimsiti, Mihaila, Pessina, Scalvini, Cittadini, Miranchuk, Pasalic
RB Leipzig: Gulacsi; Simakan, Orban, Gvardiol; Henrichs, Kampl, Laimer, Angelino; Olmo; Nkunku, Andre Silva
RB Leipzig bench: Tschauner, Martinez, Poulsen, Forsberg, Adams, Klostermann, Szoboszlai, Mukiele, Halstenberg, Raebiger, Novoa
Ref: Lahoz (ESP)