Lazio could have Ciro Immobile back in the starting line-ups against Lokomotiv Moscow, when Pedro Rodriguez seems set to start on the bench.
The match against Lokomotiv is squeezed in between the two big domestic battles with Juventus and the Partenopei, two of Sarri’s former clubs.
But the Aquile coach said his men are playing to advance in Europe and is ready to bring back Immobile to the starting line-up.
Vedat Muriqi is expected to take his place if the Italy international will show that he’s not ready to start.
Lazio are second in the group but are only three points above bottom-placed Lokomotiv, with Mareille playing Galatasaray, all fighting for a place in the knockout stages.
Thomas Strakosha seems set to start in goal, with Manuel Lazzari, Luiz Felipe, Francesco Acerbi and Elseid Hysaj in the back four.
Sergej Milinkovic-Savic and Danilo Cataldi are set to get a breather, with Lucas Leiva most likely in the middle, next to Luis Alberto and Toma Basic.
Immobile should most certainly return in the middle of an attacking trident, with Felipe Anderson and Mattia Zaccagni out wide.
Probable line-ups: Lokomotiv Moscow vs. Lazio
Lokomotiv Moscow (4-3-3): Khudiakov; Nenakhov, Jedvaj, Pablo, Rybus; Maradishvili, Barinov, Beka Beka; Kerk, Smolov, Kamano
Lazio (4-3-3): Strakosha; Lazzari, Luiz Felipe, Acerbi, Hysaj; Luis Alberto, Leiva, Basic; Felipe Anderson, Immobile, Zaccagni
Can’t afford to lose this one.