Atalanta have no available strikers, so Mario Pasalic and Ruslan Malinovskyi lead the way against Olympiacos in the Europa League play-off.
It kicks off at the Stadio Georgios Karaiskakis Piraeus at 17.45 GMT.
The first leg ended 2-1 for La Dea, who came back from an early goal with Berat Djimsiti’s brace.
Europa League Liveblog: Olympiacos-Atalanta, Lazio-Porto, Napoli-Barcelona
The away goals rule no longer applies, so if the teams are level on aggregate, it will go to extra time or even penalties.
Atalanta have no strikers left, as Luis Muriel, Duvan Zapata, Aleksei Miranchuk, Josip Ilicic and defender Jose Luis Palomino are all unavailable.
Gian Piero Gasperini’s men are without a win in five Serie A rounds and the tension is growing within the squad.
Mario Pasalic therefore becomes the False 9 rather than Jeremie Boga, supported by Matteo Pessina and Ruslan Malinovskyi.
Olympiacos again look to Tiquinho Soares, who scored the opener in Bergamo last week, with defenders Kostas Manolas and Sokratis Papastathopoulos both boasting Serie A experience.
Aguibou Camara steps in for Onyekuru in support of the striker.
Olympiacos: Vaclik; Manolas, Papastathopoulos, Cisse; Lala, M Camara, A Camara, M’Vila, Reabciuk; Tiquinho Soares, Onyekuru
Atalanta: Musso; Toloi, Demiral, Djimsiti; Hateboer, Freuler, De Roon, Maehle; Pessina, Malinovskyi; Pasalic