Luciano Spalletti seems set to rest Victor Osimhen against Legia Warszawa in the Europa League, when Alex Meret replaces David Ospina in goal.
The match at the Stadio Diego Maradona kicks off at 20.00 UK time.
Spalletti is set to make many changes ahead of the match against the group leaders in Naples and must cope without suspended Mario Rui.
Meret seems set to start in goal, while Juan Jesus should start at left-back, as Giovanni Di Lorenzo continues at right.
Kostas Manolas should be back in the heart of the defence with Kalidou Koulibaly. Spalletti could give Diego Demme and Fabian Ruiz space in the middle, with Hirving Lozano starting in the attacking trident with Eljif Elmas and Lorenzo Insigne.
Osimhen is expected to be on the bench, with Dries Mertens starting his first game of the season.
Legia are expected to arrive in a 3-5-2 formation with Mattias Johansson at right and Filip Mladenovic at left.
Probable line-ups: Napoli vs. Legia Warszawa
Napoli (4-2-3-1): Meret; Di Lorenzo, Manolas, Koulibaly, Juan Jesus; Demme, Fabian Ruiz; Lozano, Elmas, Insigne; Mertens
Legia Warszawa (3-5-2): Miszta; Jedrzejczyk, Wieteska, Nawrocki; Johansson, Slisz, Kharatin, Martins, Mladenovic; Luiquinhas, Emreli