Ciro Immobile grits his teeth and leads Lazio despite not being fully fit with Luis Alberto, Pedro and Felipe Anderson against Arkadiusz Milik and Cengiz Under for Olympique Marseille.
It kicks off at 20.00 GMT at the Stade Velodrome.
These sides drew 0-0 at the Olimpico, meaning Marseille have only stalemates in the Europa League so far this season.
Immobile is suffering from both a stomach bug and a slight knee issue, but grits his teeth and starts anyway, completing the trident with Felipe Anderson and Pedro.
Luis Alberto is again chosen to pull the midfield strings.
Marseille have a very attack-minded 3-3-1-3 formation under the guidance of coach Jorge Sampaoli.
There are several familiar faces to Serie A viewers, including ex-Napoli striker Milik, former Roma men Cengiz Under and Pau Lopez, one-time Fiorentina and Sassuolo wing-back Pol Lirola and ex-Roma midfielder Gerson.
There are no Lazio fans in the stadium because of security concerns.
Olympique Marseille: Pau Lopez; Saliba, Caleta-Car, L Peres; Lirola, Kamara, Guendouzi; Rongier, Payet, Under; Milik
Marseille bench: Ngapandouentnbu, Mandanda, Alvaro, Balerdi, Harit, Gerson, Luis Henrique, Dieng, De La Fuente, Gueye, Amavi
Lazio: Strakosha; Lazzari, Luiz Felipe, Acerbi, Hysaj; Luis Alberto, Leiva, Basic; Felipe Anderson, Immobile, Pedro
Lazio bench: Reina, Furlanetto, Patric, Esclanate, Akpa-Akpro, Romero, Milinkovic-Savic, Radu, Moro, Cataldi, Marusic, Muriqi
Ref: Sanchez (ESP)
No Lazio fans permitted by Marsielle…anti Italian bigotry.
Where are all of the SJW against bigotry?
That’s right…tge anti- bigotry movement only applies one way!