Napoli rotate the squad slightly in a must-win Europa League match against Spartak Moscow, so Andrea Petagna, Lorenzo Insigne and Matteo Politano start upfront.
It kicks off at the Stadio Diego Armando Maradona at 17.45 UK time (16.45 GMT).
The Partenopei fought back from 2-0 down with a Victor Osimhen brace to hold Leicester City 2-2 in their Europa League group phase opener, so the pressure is on to win here.
Osimhen and Hirving Lozano are rested, as is Andre-Frank Zambo Anguissa, but otherwise it’s practically a full-strength side.
Alex Meret returns in goal for the first time since fracturing a bone in his back.
Napoli are top of the Serie A table with a 100 per cent record after six rounds, but Faouzi Ghoulam and Stanislav Lobotka are still out of action.
There are some familiar faces in the Spartak Moscow side, such as ex-Inter flop Victor Moses and former Roma striker Ezequiel Ponce.
Dutch international Quincy Promes also bolsters the front line for a team that lost 1-0 to Legia Warsaw in the opening fixture.
Napoli: Meret; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Elmas, Fabian Ruiz, Zielinski; Politano, Petagna, Insigne
Napoli bench: Idasiak, Ospina, Malcuit, Demme, Juan Jesus, Osimhen, Lozano, Rrahmani, Mertens, Ounas, Zanoli, Anguissa
Spartak Moscow: Maksimenko; Caufriez, Gigot, Dzhikiya; Moses, Litvinov, Umyarov, Z Bakaev, Ayrton; Ponce, Promes
Spartak bench: Rebrov, Selikhov, Sobolev, Lomovitski, Ignatov, Eschenko, Gaponov, Melnikov
Ref: Kruzliak (SVK)