Napoli give Dries Mertens his first start of the season with Lorenzo Insigne and Chucky Lozano in this must-win Europa League clash with Legia Warsaw.
It kicks off at the Stadio Diego Armando Maradona at 20.00 UK time (19.00 GMT).
The Partenopei are in dire need of a result here, because they were held 2-2 by Leicester City and then lost at home to Spartak Moscow when down to 10 men.
Mario Rui saw red in that game and is therefore suspended, but Mertens returns for his first start of the season after shoulder surgery over the summer.
Lozano also steps in, as Victor Osimhen and Piotr Zielinski are rested, with Juan Jesus having to fill the gaps at left-back.
Last night, Leicester came back to beat Spartak Moscow 4-3 in Russia, leaving Napoli bottom of the group and the only side still without a victory.
Legia Warsaw are the group leaders on six points from two games, so are not to be taken lightly.
Both their victories over Spartak Moscow and Leicester were 1-0 results.
Napoli: Meret; Di Lorenzo, Manolas, Koulibaly, Juan Jesus; Anguissa, Demme, Elmas; Lozano, Mertens, Insigne
Napoli bench: Idasiak, Ospina, Fabian Ruiz, Osimhen, Rrahmani, Politano, Petagna, Zanoli, Lobotka
Legia Warsaw: Miszta; Jędrzejczyk, Wieteska, Nawrocki; Johansson, Josué, Andre Martins, Luquinhas, Mladenovic; Rafael Lopes; Muci
Legia Warsaw bench: Tobiasz, Yuri Ribeiro, L M Kastrati, Emreli, Kharatin, Celhaka, Skibicki, Rose, Kostorz, Slisz
Ref: Del Cerro Grande (ESP)