Napoli can start Lorenzo Insigne, Victor Osimhen and Hirving Lozano in this trip to a revamped Leicester City, aiming to maintain their perfect start to the season.
It kicks off at the King Power Stadium at 20.00 UK time (19.00 GMT).
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The Partenopei have won all three games under new coach Luciano Spalletti, including Saturday’s 2-1 comeback success over Juventus.
Captain Insigne was an injury doubt, but he is in the starting XI with Osimhen, Piotr Zielinski and Lozano, giving Matteo Politano some rest.
Ex-Fulham midfielder Andre-Frank Anguissa made a strong impression on his debut and starts again in midfield, as Diego Demme is out of action.
Leicester City are famous for winning the Premier League under Claudio Ranieri, bit also took silverware last season, beating Chelsea in the FA Cup Final.
Surprisingly, Brendan Rodgers rests both Jamie Vardy and Youri Tielemans, so Kelechi Iheanacho leads the attack.
Ex-Atalanta wing-back Timothy Castagne is joined by returning Yannick Vestergaard.
Leicester City: Schmeichel; Castagne, Vestergaard, J Evans, Bertrand; Perez, Ndidi, Soumare; Daka, Iheanacho, Barnes
Leicester City bench: Ward, Caglar Soyuncu, Tielemans, Vardy, Maddison, Albrighton, Amartey, Choudhury, Ricardo Pereira, Dewsbury-Hall, Thomas, Lookman
Napoli: Ospina; Malcuit, Rrahmani, Koulibaly, Di Lorenzo; Anguissa, Fabian Ruiz, Zielinski; Lozano, Osimhen, Insigne
Napoli bench: Idasiak, Boffelli, Nunes Jesus, Elmas, Politano, Ounas, Petagna, Manolas, Zanoli
Ref: Tiago Martins (POR)