Napoli are forced to reshuffle with Hirving Lozano and Andrea Petagna upfront in this top of the group showdown with Legia Warsaw.
It kicks off in Poland at 17.45 GMT.
The Partenopei got their first win of the Europa League season by crushing Legia Warsaw 3-0 at the Stadio Diego Armando Maradona, but the Polish side remain top of the group on six points.
This is an opportunity to leapfrog the leaders, but Luciano Spalletti has made the journey without Victor Osimhen, Lorenzo Insigne, Fabian Ruiz, Kevin Malcuit, Kostas Manolas and suspended Mario Rui.
Petagna therefore becomes the centre-forward, with support from Lozano, Piotr Zielinski and Eljif Elmas.
Legia Warsaw are top of the group, but still recently sacked coach Czeslaw Michniewicz to bring in Marek Golebiewski, promoted from the reserves team.
That is because their domestic form has been awful, with nine points after 11 games in the Polish Ekstraklasa.
Veteran shot-stopper Artur Boruc is still out of action.
Legia Warsaw: Miszta; Johansson, Wieteska, Jedrzejczyk; Ribeiro, Josué, Slisz, Mladenovic; Kastrati, Emreli, Luqinhas
Legia Warsaw bench: Tobiasz, Andre Martins, Pekhart, Kharatin, Celhaka, Muci, Rafael Lopes, Skibicki, Wlodarczyk, Rose, Kostorz, Ciepela
Napoli: Meret: Di Lorenzo, Rrahmani, Koulibaly, Juan Jesus; Demme, Anguissa; Lozano, Zielinski, Elmas; Petagna
Napoli bench: Isasiak, Ospina, Mertens, Politano, Ounas, Zanoli, Lobotka
Ref: Visser (BEL)