Lazio look to Ciro Immobile, Felipe Anderson and Sergej Milinkovic-Savic in a must-win Europa League match with Olympique Marseille, as Arkadiusz Milik, Cengiz Under and Pau Lopez return to Italy.
It kicks off at the Stadio Olimpico at 17.45 UK time (16.45 GMT).
The Biancocelesti had a mixed bag in Europe so far under Maurizio Sarri, losing 1-0 away to Galatasaray due to a Thomas Strakosha howler, then beating Lokomotiv Moscow 2-0.
Jorge Sampaoli’s Marseille drew both their fixtures so far against the same teams and sit third in Group E.
As they are suspended in Serie A this weekend, Francesco Acerbi and Luiz Felipe both start, while Luis Alberto is dropped again after he was benched for the 3-1 Serie A wi over Inter.
There’s no rest for Immobile and Felipe Anderson, but Mattia Zaccagni is back after injury.
Marseille have several former Serie A players in the side, such as ex-Roma men Pau Lopez and Cengiz Under, while Milik worked with Sarri at Napoli.
Dimitri Payet starts with ex-Fiorentina wing-back Pol Lirola.
Lazio: Strakosha; Lazzari, Luiz Felipe, Acerbi, Marusic; Milinkovic-Savic, Cataldi, Basic; Felipe Anderson, Immobile, Zaccagni
Lazio bench: Reina, Furlanetto, Patric, Escalante, Leiva, Akpa-Akpro, Pedro, Luis Alberto, Hysaj, Radu, Moro, Muriqi
Olympique Marseille: Pau Lopez; Saliba, Caleta-Car, Luan Peres; Lirola, Rongier, Kamara, Guendouzi, Cengiz Under; Payet; Milik
Marseille bench: Ngapandouentnbu, Mandanda, Alvaro, Balerdi, Harit, Gerson, Luis Henrique, Dieng, De La Fuente, Gueye, Amavi, Sciortino
Ref: Aytekin (GER)