Lazio give Mattia Zaccagni his first start with Ciro Immobile, Felipe Anderson and Luis Alberto in this difficult Europa League trip to Fatih Terim’s Galatasaray.
It kicks off in Istanbul at 17.45 UK time (16.45 GMT).
The Biancocelesti are fresh off their first defeat of the season, 2-0 to Milan, and coach Maurizio Sarri is still trying to get his system drilled into a squad accustomed to 3-5-2 for so many years.
It’s a tough Europa League group with Olympique Marseille and Lokomotiv Moscow, so a good start is essential in Turkey.
Sarri was expected to rotate his squad far more, but there are relatively few changes to the starting XI.
Zaccagni gets his first start since the move from Verona, but Sergej Milinkovic-Savic and Pedro are the only ones really rested, as Immobile, Felipe Anderson and Luis Alberto still start.
Former Fiorentina and Milan coach Fatih Terim is a legend for Galatasaray, now in his fourth stint at the club.
Marcao returns to the pitch, as he is sitting out an eight-match domestic ban after attacking his own teammate Kerem Akturkoglu during a game against Giresunspor.
Sacha Boey and Baris Yilmaz are both carrying injuries and the team had a rough start to the season, twice throwing away 2-0 leads for 2-2 draws.
Galatasaray: Muslera; Yedlin, Marcao, Nelsson, Van Aanholt; Kutlu, Antalyali; Morutan, Cicaldau, Akturkoglu; Dervisoglu
Galatasaray bench: Cipe, Ozturk, Babel, Mohamed, Omer Bayram, Kaan Arslan, Luyindama, Atalay Babacan, Emre Kilinc, Feghouli, Diagne
Lazio: Strakosha; Lazzari, Luiz Felipe, Acerbi, Hysaj; Akpa-Akpro, Leiva, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Lazio bench: Reina, Furlanetto, Patric, Escalante, Pedro, Milinkovic-Savic, Radu, Moro, Cataldi, Marusic, Basic, Muriqi
Ref: Jug (SVN)