Roma look to Romelu Lukaku, Stephan El Shaarawy and Renato Sanches in the Europa League opener away to Sheriff Tiraspol.
It kicks off in Transinistria, a breakaway state within Moldova, at 17.45 UK time (16.45 GMT).
The Giallorossi reached the Europa League Final last season, losing only on penalties to Sevilla after a contentious 1-1 draw.
Jose Mourinho’s fury at the refereeing decisions means he is suspended for the first four games of this group phase, which also includes Slavia Prague and Servette.
Also absent are injured Chris Smalling, Lorenzo Pellegrini, Tammy Abraham and Marash Kumbulla.
They had one point from the opening three Serie A rounds, until smashing sorry Empoli 7-0 at the Olimpico on Sunday.
Squad rotation includes El Shaarawy and goalkeeper Mile Svilar, while Houssem Aouar returns after a knock.
Sheriff Tiraspol have an Italian coach, Roberto Bordin, who is in his second stint at this club after a brief spell as manager of Moldova.
Captain Amine Talal returns from suspension, with Vinicius Paiva, Rasheed Akanbi and Moussa Kyabou injured.
This team was originally in the Champions League preliminary rounds, eliminated by Maccabi Haifa in extra time last month.
Sheriff: Koval; Tovar, Kiki, Garananga, Artunduaga; Zohouri, Ademo, Fernandes; Ankeye, Talal, Ngom Mbekeli
Roma: Svilar; Mancini, Llorente, Ndicka; Karsdorp, Renato Sanches, Cristante, Aouar, Zalewski; Lukaku, El Shaarawy
Ref: Treimanis (LVA)
|65'||Romelu Lukaku |
(Assist: Bryan Cristante)