Roma look to Romelu Lukaku, Andrea Belotti and Renato Sanches against Sheriff, knowing even a win might not be enough to take top spot in the Europa League group.
It kicks off at the Stadio Olimpico at 20.00 GMT.
The Giallorossi already know they are through to the next round, but first place means avoiding the play-offs with a side that drops down from the Champions League.
Their odds are slim, as they need to beat Sheriff and hope Slavia Prague lose to Servette, or win by over four clear goals as long as Slavia draw to turn overall goal difference their way.
The injury crisis is cranking up again with Paulo Dybala, Leonardo Spinazzola and Sardar Azmoun joining long-term absentees Chris Smalling, Marash Kumbulla and Tammy Abraham.
Jose Mourinho confirmed a ‘more or less’ change to a four-man defence, with Gianluca Mancini not fully fit either and Evan Ndicka suspended, as the focus has to be on the upcoming showdown for Serie A fourth place with Bologna.
Rasmus Kristensen and Azmoun are also not even on the UEFA list due to Financial Fair Play limitations.
Sheriff Tiraspol are rock bottom of the group with just one point, so have nothing to play for.
When these sides met in September, Roma emerged 2-1 winners.
Roma: Svilar; Celik, Cristante, Llorente; Karsdorp, Renato Sanches, Aouar, Bove, Zalewski; Belotti, Lukaku
Sheriff: Koval; Apostolakis, Tovar, Garananga, Artun Duaga; Ngom Mbekeli, Talal, Badolo, Fernandes; Ankeye, Ricardinho
Ref: Brisard (FRA)
Player statistic
| Romelu Lukaku (Assist: Nicola Zalewski) |
 |
11' | ||
| 24' |  |
Amine Talal | ||
| Andrea Belotti | |
32' |
| 61' | |
Ricardinho | ||
| Edoardo Bove | |
77' | ||
| Niccolò Pisilli (Assist: Romelu Lukaku) |
|
90+3' |
Match statistic
