Romelu Lukaku, Andrea Belotti and Houssem Aouar lead the way for Roma against Servette in the Europa League, while Bryan Cristante again fills in for the defence.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
The Giallorossi have had a tough campaign so far, but seem to be turning things around with a 2-1 victory away to Sheriff Tiraspol in Europe and 2-0 Serie A result against Frosinone.
Jose Mourinho still has a decimated squad, especially in defence, where Chris Smalling, Diego Llorente and Marash Kumbulla are all out of action, so Cristante drops back to deputise.
Renato Sanches and Tammy Abraham are also on the treatment table, while Paulo Dybala needs rest, so Belotti partners Lukaku this time around.
It is a sixth consecutive start for the Belgian.
Aouar returns to the middle of the park after recovering from injury and once again Mile Svilar gets the gloves in Europe.
Servette lost their opening Europa League tie 2-1 against Slavia Prague, but saw their nine-match winless streak in all competition ended with a 2-1 victory over Lausanne at the weekend.
Jeremy Frick is back in the squad, but Jerome Onguene, Anthony Baron, Theo Magnin and Alexander Lyng have not made the trip, with centre-back Steve Rouiller not fully fit.
Chris Bedia is the danger man upfront with eight goals in 15 competitive games this season.
Roma: Svilar; Mancini, Cristante, Ndicka; Celik, Bove, Paredes, Aouar, El Shaarawy; Lukaku, Belotti
Servette: Frick; Tsunemoto, Vouilloz, Severin, Mazikou; Kutesa, Antunes, Ondua, Stevanovic; Bedia, Crivelli
Ref: Pajac (CRO)
Player statistic
| Romelu Lukaku (Assist: Zeki Celik) |
 |
22' |
| Andrea Belotti (Assist: Lorenzo Pellegrini) |
|
46' | ||
| Lorenzo Pellegrini (Assist: Zeki Celik) |
|
52' | ||
| Andrea Belotti (Assist: Leandro Paredes) |
|
59' | ||
| 71' |  |
Gaël Ondoua | ||
| 81' | |
David Douline |
Match statistic
