Roma start Tammy Abraham with Paulo Dybala and Nicolò Zaniolo in a big Europa League clash with Real Betis.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
The Giallorossi are brimming with confidence after their Serie A victory away to Inter, but also suffered some painful defeats this season against Udinese, Atalanta and Ludogorets.
Lorenzo Pellegrini, Rick Karsdorp and Georginio Wijnaldum are injured, but Abraham returns to the starting XI, supported by Zaniolo and Dybala.
If Roma win, then it will be Jose Mourinho’s 107th UEFA competition victory, allowing him to surpass Carlo Ancelotti and Sir Alex Ferguson as the most successful coach in European football.
Betis are top of the group with a 100 per cent record, having beaten HJK 2-0 and Ludogorets in a 3-2 thriller, and won the 2021-22 Spanish Cup.
Juanmi is out injured, while Loren Morón and Martin Montoya are not in the Europa League squad.
It is a return to the Stadio Olimpico for former Lazio defender Luiz Felipe Ramos and ex-Fiorentina centre-back German Pezzella.
Captain Joaquin is also still going strong at the age of 41, formerly of Fiorentina.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Celik, Cristante, Matic, Zalewski; Zaniolo, Dybala; Abraham
Real Betis: Bravo; Altor Ruibal, Pezzella, Luiz Felipe, Miranda; Rodriguez, Guardado; Canales, Fekir, Joaquin; Willian Jose
Ref: Jug (SVN)