Paulo Dybala starts for Roma, but Tammy Abraham is only fit for the bench in this must-win Europa League play-off against RB Salzburg.
It kicks off at the Stadio Olimpico at 20.00 GMT.
The Giallorossi lost the first leg in Austria 1-0, so as away goals no longer count double in Europe, they need to win by two clear goals to qualify for the Europa League Round of 16.
If they win by one clear goal tonight, then it is level on aggregate and goes to extra time.
The build-up was dominated by injury concerns, as Abraham needed stitches for a cut to his eyebrow on Sunday and should be able to play with a special protective mask, which includes a clear section allowing him to see out of his left eye.
However, the England international is not risked from the start, unlike Dybala after recovering from muscular issues.
Defender Strahinja Pavlovic is suspended for RB Salzburg, so Bernardo steps in, while Luka Sucic supports strikers Adamu and Noah Okafor, leaving Benjamin Sesko on the bench.
Nicolas Capaldo scored the late winner in Austria for the side that dropped down from Milan and Chelsea’s Champions League group.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Spinazzola, Cristante, Matic, Zalewski; Pellegrini, Dybala; Belotti
RB Salzburg: Kohn; Dedic, Bernardo, Solet, Ulmer; Capaldo, Gourna-Douath, Seiwald, Kjaergaard; Okafor, Adamu
Player statistic
Roger Ibañez | 4' | |||
Lorenzo Pellegrini | 5' | |||
Andrea Belotti | 33' | |||
Paulo Dybala (Assist: Leonardo Spinazzola) |
40' |
Leonardo Spinazzola | 54' | |||
Nicola Zalewski | 74' |