Roma have no choice but to win against Ludogorets if they want to continue in the Europa League, but Nicolò Zaniolo does not start after his ban was reduced on appeal, so Andrea Belotti supports Tammy Abraham.
It kicks off at the Stadio Olimpico at 20.00 GMT.
The Giallorossi cannot catch Real Betis at the top, so their only hope of qualification for the play-offs is to beat Ludogorets.
Failing that, they will go into the Conference League and try to defend the title they won last season.
Zaniolo was originally handed a three-match ban for violent conduct, reduced on appeal, but he is rested anyway as he is not 100 per cent fit.
Gianluca Mancini is suspended, with Leonardo Spinazzola, Paulo Dybala, Georginio Wijnaldum and Ebrima Darboe injured.
Jose Mourinho has to resist any temptation to rest more players ahead of Sunday’s crucial Serie A Derby della Capitale against Lazio.
Ludogorets won 2-1 when these sides met in Bulgaria, so if this ends in a draw and both on eight points, they will go through thanks to a superior head-to-head record.
Former Cagliari striker Kiril Despodov has been out with a thigh injury for three weeks.
Roma: Rui Patricio; Smalling, Ibanez, Vina; Karsdorp, Matic, Camara, Pellegrini, El Shaarawy; Belotti, Abraham
Ludogorets: Padt; Witry, Verdon, Nedyalkov, Cicinho; Piotrowski, Naressi; Tekpetey, Cauly, Rick; Thiago