Roma rely on Romelu Lukaku and Paulo Dybala for the Europa League showdown with Roberto De Zerbi’s Brighton and Hove Albion.
The first leg of the Round of 16 kicks off at the Stadio Olimpico at 17.45 GMT.
The Giallorossi have been a transformed team since Daniele De Rossi took over from Jose Mourinho, knocking Feyenoord out of the play-offs and earning six wins and a single defeat to Inter in Serie A.
Rasmus Kristensen is injured anyway, while Dean Huijsen and Sardar Azmoun are also ineligible for the Europa League, and Tammy Abraham a long-term absentee.
Rick Karsdorp is not fully fit either, so Zeki Celik starts at right-back, while Lorenzo Pellegrini and Leandro Paredes support Dybala, Lukaku and Stephan El Shaarawy.
De Zerbi has earned plenty of new fans during his time at Brighton, prompting links with the job at Milan, Liverpool, Barcelona, Chelsea and Bayern Munich.
He achieved that by getting the Seagulls into their first ever European campaign and then topping the group.
Former Fiorentina defender Igor is in defence, while Billy Gilmour is available because his three-match ban only applies to the Premier League.
Joao Pedro, Kaoru Mitoma, Solly March, James Milner and Jack Hinshelwood are injured.
Veteran Danny Welbeck leads the attack after he was rested for the defeat to Fulham, with support from Facundo Buonanotte, leaving Barcelona-owned talent Ansu Fati on the bench.
Roma: Svilar; Celik, Mancini, Ndicka, Spinazzola; Cristante, Paredes, Pellegrini; Dybala, Lukaku, El Shaarawy
Roma bench: Rui Patricio, Boer, Karsdorp, Smalling, Llorente, Azmoun, Renato Sanches, Aouar, Baldanzi, Bove, Zalewski, Angelino
Brighton: Steele; Igor, Dunk, van Hecke; Lamptey, Gilmour, Gross, Adingra; Buonanotte, Enciso; Welbeck
Brighton bench: Verbruggen, McGill, Webster, Lallana, Moder, Baleba, Ferguson, Estupinan, Fati, Veltman, Peupion, Baker-Boaitey
Ref: Letexier (FRA)
Player statistic
| Paulo Dybala (Assist: Leandro Paredes) |
 |
12' | ||
| 38' |  |
Jan Paul van Hecke | ||
| Romelu Lukaku | |
43' |
| Leonardo Spinazzola | |
61' | ||
| Gianluca Mancini (Assist: Stephan El Shaarawy) |
|
64' | ||
| 67' | |
Tariq Lamptey | ||
| Bryan Cristante (Assist: Stephan El Shaarawy) |
|
68' |
Match statistic
