Roma defend a 2-0 first leg lead for this Europa League Round of 16 trip to Real Sociedad, with Paulo Dybala, Andrea Belotti and wearing a protective helmet Lorenzo Pellegrini.
It kicks off at the Anoeta Stadium in San Sebastian at 20.00 GMT.
The Giallorossi are still fuming after their 4-3 Serie A home defeat to Sassuolo, which saw Marash Kumbulla sent off for a reaction foul.
Compared to that game, Dybala is fully fit, while Pellegrini can start with a protective helmet after needing 30 stitches to his head for an accidental collision with Real Sociedad’s Igor Zubeldia.
Diego Llorente limped off in that game and is out injured, but Roger Ibanez returns from his ban.
The Derby della Capitale with rivals Lazio is coming up on Sunday evening, but Jose Mourinho cannot afford to rotate his squad.
Nemanja Matic is not even on the bench after coming down with a stomach bug.
Real Sociedad are still missing Aritz Elustondo and former Roma striker Umar Sadiq.
Mikel Oyarzabal, David Silva and Alexander Sorloth upfront, leaving Takefusa Kubo start on the bench.
Real Sociedad: Remiro; Gorosabel, Le Normand, Zubeldia, Rico; Brais Mendez, Zubimendi, Merino; David Silva; Sorloth, Oyarzabal
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Wijnaldum, Spinazzola; Pellegrini, Dybala; Belotti
Ref: Kovacs (ROU)
Player statistic
6' | Rick Karsdorp | |||
Igor Zubeldia | 13' | |||
17' | Gianluca Mancini | |||
Diego Rico | 39' |
Carlos Fernández | 88' | |||
Carlos Fernández | 90+8' | |||
90+8' | Chris Smalling |