Atalanta field an experimental line-up against Polish side Rakow including Luis Muriel, Charles De Ketelaere and a couple of debutant defenders.
It kicks off at the Zaglebiowski Park Sportowy in Sosnowiec at 20.00 GMT.
La Dea have already guaranteed first place and passage straight into the Europa League Round of 16, so have nothing to really play for here other than pride and UEFA ranking.
Nonetheless, Muriel and De Ketelaere still start upfront, as Gianluca Scamacca and El Bilal Toure are out of action, with Teun Koopmeiners left at home.
The biggest injury problems are in defence, where the absentee list includes Sead Kolasinac, Jose Luis Palomino and Rafael Toloi.
There are therefore full debuts for youth academy products Giovanni Bonfanti and Tommaso Del Lungo.
When these sides met in September, it was a 2-0 victory for Atalanta, but Rakow Czestochowa are bottom of the group alongside Sturm Graz on four points each.
That means they can still get third place and access to the Conference League play-offs, so there is plenty of motivation.
Kamil Pestka, Adrian Gryskiewicz, Ivi Lopez and Giannis Papanikolaou are all on the treatment table.
Rakow: V Kovacevic; Racovitan, A Kovacevic, Rundic; Tudor, Kochergin, Berggren, Plavsic; Yeboah, Zwolinski, Nowak
Atalanta: Carnesecchi; Hateboer, Bonfanti, Del Lungo; Holm, Adopo, Pasalic, Zortea; Miranchuk; De Ketelaere, Muriel,
Ref: Jorgi (ALB)
Player statistic
| 14' |  |
Luis Muriel (Assist: Aleksey Miranchuk) | ||
| 27' | |
Giovanni Bonfanti | ||
| 33' |  |
Emil Holm |
| 73' | |
Luis Muriel | ||
| Fran Tudor | |
75' | ||
| 79' | |
Giovanni Bonfanti | ||
| 90+2' | |
Charles De Ketelaere |
Match statistic
