Rafael Leao, Olivier Giroud and Christian Pulisic lead a full-strength Milan against Slavia Praha in the Europa League Round of 16.
The first leg kicks off at San Siro at 20.00 GMT.
Stefano Pioli is taking no chances in this tournament, which is their last chance to win silverware this season, as well as a trophy that the club has never lifted.
Only Tommaso Pobega is still out injured, so Giroud leads the attack with support from Pulisic, Ruben Loftus-Cheek and Leao.
Tijjani Reijnders returns in midfield after he was rested for the chaotic 1-0 win over eight-man Lazio, while Alessandro Florenzi gets the nod at right-back, largely because he is suspended in Serie A anyway.
Slavia Praha topped the Europa League group ahead of Roma, having won every single game except for a 2-0 defeat at the Stadio Olimpico in October.
They also lost only one match all season domestically and are in second place, four points behind local rivals Sparta.
Stanislav Tecl, Bolu Ogungbayi, Sheriff Sinyan and David Pech are ineligible for this competition, with star midfielder Christos Zafeiris, goalkeeper Ondrej Kolar and Petr Sevcik injured.
Mojmir Chytil is their top scorer this season with 15 goals, four of them in five Europa League games, while defender David Zima joined from Torino in January.
Milan: Maignan; Florenzi, Kjaer, Gabbia, Theo Hernandez; Adli, Reijnders; Pulisic, Loftus-Cheek, Leao; Giroud
Milan bench: Sportiello, Mirante, Calabria, Bennacer, Jovic, Okafor, Kalulu, Chukwueze, Tomori, Thiaw, Terracciano, Musah
Slavia Praha: Stanek; Vicek, Holes, Zima, Diouf; Dorley, Masopust; Doudera, Provod, Zmrzly; Chytil
Slavia Praha bench: Mandous, Sirotnik, Ogbu, Wallem, Tijani, Van Buren, Jurecka, Boril, Schranz, Tomic, M Jurasek, Konecny
Ref: Meler (TUR)
Player statistic
| Alessandro Florenzi |  |
2' | ||
| 26' |  |
El Hadji Malick Diouf | ||
| Olivier Giroud |  |
34' | ||
| 36' | |
David Doudera | ||
| Tijjani Reijnders (Assist: Alessandro Florenzi) |
|
44' | ||
| Ruben Loftus-Cheek (Assist: Alessandro Florenzi) |
|
45+1' |
| 65' | |
Ivan Schranz | ||
| Davide Calabria | |
72' | ||
| Christian Pulisic (Assist: Rafael Leão) |
|
85' |
Match statistic
