Roma revamp with Andrea Belotti and Mile Svilar making their first starts in the Europa League away to Ludogorets.
It kicks off at 17.45 UK time (16.45 GMT) in Razgrad.
Group C is completed by Real Betis and HJK Helsinki.
The Giallorossi saw their season shaken up badly by a 4-0 defeat to Udinese at the weekend and injuries are piling up too.
Tammy Abraham and Rick Karsdorp didn’t make the trip, with Marash Kumbulla, Nicolò Zaniolo, Stephan El Shaarawy and Georginio Wijnaldum already out.
Goalkeeper Svilar makes his debut and Belotti gets his first start, supported by Paulo Dybala and Lorenzo Pellegrini.
Former Cagliari striker Kiril Despodov starts for Ludogorets with Igor Thiago rather than Matias Tissera.
Ludogorets: Padt; Cicinho, Verdon, Witry, Nedyalkov; Cauly, Piotrowski, Cafumana; Tekpetey, Thiago, Despodov
Roma: Svilar; Mancini, Smalling, Ibanez; Celik, Cristante, Matic, Zalewski; Dybala, Pellegrini; Belotti