Taty Castellanos, Fisayo Dele-Bashiru and Pedro start for Lazio as they try to keep their Europa League success rate going against Jeremie Boga’s OGC Nice.
It kicks off at the Stadio Olimpico at 17.45 UK time (16.45 GMT).
You can follow all the build-up and action as it happens from this game, Elfsborg-Roma and Fiorentina-The New Saints on the Liveblog.
The Aquile opened their European adventure with a comfortable 3-0 victory over Dynamo Kyiv on neutral turf, so aim to keep their perfect record intact with added home advantage.
Castellanos returns from injury, supported by Dele-Bashiru in his more advanced role, veteran Pedro and Loum Tchaouna.
Patric is also back after a muscular problem following the 3-2 win away to Torino in Serie A.
Tijjani Noslin is suspended after his red card in Europe, with Samuel Gigot still injured.
Nice were held 1-1 by Real Sociedad in their opening Europa League tie and drew 0-0 with RC Lens in Ligue 1 on Saturday.
Melvin Bard, Morgan Sanson, Gaetan Laborde and Terem Moffi are out of action, but while Moise Bombito is suspended in Ligue 1, he is free to play in defence here.
Former Sassuolo and Atalanta winger Jeremie Boga plays following his €17m transfer.
Lazio vs. Nice line-ups
Lazio: Mandas; Marusic, Patric, Gila, Pellegrini; Guendouzi, Vecino; Tchaouna, Dele-Bashiru, Pedro; Castellanos
Nice: Bulka; Ndayshimiye, Bombito, Dante; Clauss, Rosario, Boudaoui, Louchet; Boga, Bouanani; Moukoko
Ref: Fesnic (ROU)
Player statistic
| 19' |  |
Tom Louchet | ||
| Pedro |  |
20' | ||
| Taty Castellanos | |
35' | ||
| 41' | |
Jeremie Boga (Assist: Youssoufa Moukoko) |
| 51' | |
Moïse Bombito | ||
| Taty Castellanos (Assist: Nicolò Rovella) |
|
53' |
