Juventus try to restore some pride in the Europa League and host FC Nantes with Dusan Vlahovic, Angel Di Maria and Federico Chiesa.
This play-off kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
The second leg is in France on Thursday February 23.
The Bianconeri had a simply awful Champions League experience and by scraping third place they dropped down into the Europa League.
Considering their 15-point penalty in Serie A, winning this tournament may well be their best shot at qualifying for the Champions League next season.
Paul Pogba and Kaio Jorge are still out injured, while Mattia Perin has flu, but Di Maria, Vlahovic and Chiesa form the trident attack for the second game running.
Nantes finished second in their Europa League group behind Freiburg, yet they are struggling badly in Ligue 1 and sit in 13th place.
The build-up to this game has been marred by unimaginable tragedy, so centre-forward Ignatius Ganago is on compassionate leave following the death of his five-year-old daughter.
Mostafa Mohamed leads the line and is their top scorer this season with eight goals in all competition, while left-back Quentin Merlin is injured.
These clubs famously crossed paths in the 1996 Champions League semi-finals.
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; De Sciglio, Fagioli, Paredes, Rabiot, Chiesa; Di Maria, Vlahovic
Nantes: Lafont; Girotto, Pallois, Castelletto; Centonze, Sissoko, Chirivella, Moutoussamy, Coco; Blas; Mostafa Mohamed
Player statistic
| Dusan Vlahovic (Assist: Federico Chiesa) |
 |
13' | ||
| 45+1' |  |
Jean-Charles Castelletto |
| Federico Chiesa | |
54' | ||
| 57' | |
Mostafa Mohamed | ||
| 60' | |
Ludovic Blas (Assist: Mostafa Mohamed) | ||
| Danilo | |
75' | ||
| 90' | |
Sébastien Corchia |
Match statistic
