Juventus hope Dusan Vlahovic and Moise Kean can build on the 1-0 first leg lead as they visit Freiburg in the Europa League Round of 16, as Angel Di Maria and Federico Chiesa are only fit for the bench.
It kicks off at the Stadion am Wolfswinkel at 17.45 GMT.
The Bianconeri won the first leg 1-0 thanks to Di Maria’s header, but he is only fit for the bench along with Chiesa after picking up muscular problems.
Paul Pogba, Arkadiusz Milik, Leonardo Bonucci, Fabio Miretti and Alex Sandro are injured, so Federico Gatti steps into the back three, with Vlahovic and Kean upfront.
Italy international Vincenzo Grifo is surprisingly dropped to the bench.
Michael Gregoritsch and Ritsu Doan can start after only being substitutes in the first leg due to illness.
Phillipp Lienhart was a doubt until the last minute with a thigh issue and is not even on the bench.
Daniel-Kofi Kyereh is out for the rest of the season with a torn anterior cruciate ligament, though Woo-yeong Jeong returns.
Coach Christian Streich signed a new contract with the Bundesliga side this week.
Freiburg: Flekken; Sildilia, Gulde, Ginter; Kubler, Eggestein, Hofler, Gunter; Holer, Doan; Gregoritsch
Juventus: Szczesny; Gatti, Bremer, Danilo; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Kean, Vlahovic
Ref: Gozubuyuk (NED)
Player statistic
Nicolas Höfler | 4' | |||
Manuel Gulde | 26' | |||
Manuel Gulde | 44' | |||
45' | Dusan Vlahovic |
56' | Dusan Vlahovic | |||
82' | Samuel Iling Junior | |||
Roland Sallai | 87' | |||
90+5' | Federico Chiesa (Assist: Adrien Rabiot) |