Paulo Dybala and Romelu Lukaku lead the way for Roma with a few changes in the Europa League play-off against Feyenoord, who have Santiago Gimenez on the bench.
It kicks off in Rotterdam at 17.45 GMT.
The Giallorossi won their first three matches under Daniele De Rossi before the dramatic 4-2 defeat to Inter at the weekend.
Bryan Cristante is struggling with fitness concerns, so Edoardo Bove steps into midfield, with Angelino rested in favour of Leonardo Spinazzola.
As with Jose Mourinho’s era, Mile Svilar is the goalkeeper for cup competitions, but it is the new front three of Dybala, Lukaku and in a more advanced role Nicola Zalewski, who had been used as a wing-back by Mourinho.
Evan Ndicka is still out after winning the Africa Cup of Nations with the Ivory Coast.
Tammy Abraham is injured, while Dean Huijsen and Rasmus Kristensen are not on the UEFA list.
Feyenoord lost to Roma in the 2022 Conference League Final and again in last season’s Europa League quarter-final, but due to ugly scenes in previous clashes, the fans are barred from travelling for their games.
Goalkeeper Justin Bijlow, Quinten Timber, Gernot Trauner, Lutsharel Geertruida, Thomas van den Belt and Gjivai Zechiel are on the treatment table.
The big doubt was over Mexico international and top scorer Santiago Gimenez, who has 21 goals in 28 competitive games this season.
He was suspended for the first two Champions League group matches due to the red card he received against Roma, then missed the weekend’s 2-0 win over Sparta Rotterdam with a calf strain.
Feyenoord: Wellenreuther; Nieuwkoop, Hancko, Beelen, Hartman; Stengs, Zerrouki, Wieffer; Minteh, Ueda, Paixao
Roma: Svilar; Karsdorp, Mancini, Llorente, Spinazzola; Bove, Paredes, Pellegrini; Dybala, Lukaku, Zalewski
Ref: Petrescu (ROM)
Player statistic
Thomas Beelen | 14' | |||
Yankuba Minteh | 35' | |||
Igor Paixão (Assist: Quilindschy Hartman) |
45+1' |
46' | Diego Llorente | |||
67' | Romelu Lukaku (Assist: Leonardo Spinazzola) | |||
Calvin Stengs | 69' | |||
86' | Edoardo Bove |