Atalanta open their Europa League campaign by hosting Champions of Poland Rakow with Charles De Ketelaere, Luis Muriel and Ademola Lookman upfront.
It kicks off at the Gewiss Stadium at 20.00 UK time (19.00 GMT).
La Dea are coming off a 3-2 Serie A defeat to Fiorentina and have lost Gianluca Scamacca for a month due to a muscular injury, with El Bilal Toure also out of action until 2024.
It means De Ketelaere supports Lookman and Muriel, moving Teun Koopmeiners into a deeper role.
Rakow were rather a small club until they were taken over by one of the richest men in Poland, culminating in the league title last season.
Captain Zoran Arsenic is out injured along with Stratos Svarnas and Adrian Gryszkiewicz.
Another big loss is Fran Tudor, who needed a late fitness test and is not even on the bench.
Atalanta: Musso; Toloi, Djimsiti, Scalvini; Zappacosta, De Roon, Koopmeiners, Ruggeri; De Ketelaere; Lookman, Muriel
Rakow: V Kovacevic; Racovitan, A Kovacevic, Rundic; Sorescu Papanikolaou, Berggren, Plavsic; Kochergin, Zwolinski, Yeboah
Ref: Reinshreiber (ISR)