Italy CT Roberto Mancini seems set to give Marco Verratti the nod, whilst Domenico Berardi continues at right in the attacking trident against Austria.
The match at Wembley in London kicks off at 20.00 UK time.
The Azzurri have travelled to the English capital to continue their path at the Euros and prepare to face Austria on Saturday night.
After three consecutive wins and clean sheets, Mancini changes back to his starting line-up from the first two matches in Group A after making eight changes in the 1-0 win over Wales.
Up front, the trident used in the two first games are expected to start, with Berardi, Ciro Immobile and Lorenzo Insigne all impressing in the two 3-0 wins over Turkey and Switzerland.
Giovanni Di Lorenzo returns to the starting line-up, as he replaced Alessandro Florenzi in the first game and continued at right-back in the second, meaning Rafael Toloi is back on the bench in London.
Verratti returned to the team against Wales and was given the captaincy when Leonardo Bonucci went off at half-time.
The Paris Saint-Germain star is expected to continue at left in a midfield trident, replacing Manuel Locatelli, who starred in the first two games of the group stage.
Francesco Acerbi will step in for injured Giorgio Chiellini and team up with Bonucci in the heart of the defence, whilst Leonardo Spinazzola returns to left-back.
Austria CT Franco Foda seems set to have Christoph Baumgartner back in time for the clash at Wembley, as the Hoffenheim midfielder suffered a blow against Sweden but recovered and should start next to Marcel Sabitzer.
Former Inter attacker Marko Arnautovic is expected to start up front for the Austrians, who are expected to play a 4-3-2-1 formation with David Alaba at left in the back four.
Italy (4-3-3): Donnarumma; Di Lorenzo, Bonucci, Acerbi, Spinazzola; Barella, Jorginho, Verratti; Berardi, Immobile, Insigne
Austria (4-3-2-1): Bachmann; Lainer, Dragovic, Hinteregger, Alaba; Schlager, Grillitsch, Laimer; Sabitzer, Baumgartner; Arnautovic
Ref: Taylor (ENG)