Angel Di Maria and Federico Chiesa are in the Juventus squad to face Inter, along with NextGen talent Nikola Sekulov, but Paul Pogba, Moise Kean and Alex Sandro miss out.
The Derby d’Italia kicks off at San Siro on Sunday at 19.45 GMT.
The Bianconeri go into this game without suspended Kean, who was given a two-match Serie A ban for his reaction foul just 40 seconds into a substitute appearance against Roma.
Also absent are injured Fabio Miretti, Pogba, Alex Sandro, Arkadiusz Milik and Kaio Jorge, but Leonardo Bonucci does return after missing Thursday’s 2-0 Europa League victory away to Freiburg.
Chiesa came off the bench for 20 minutes in that game and scored a goal, while Di Maria was rested due to a muscular issue, but the Argentine should start tomorrow.
Manuel Locatelli is the favourite to take over in midfield, ahead of Leandro Paredes and Enzo Barrenechea.
Max Allegri continues to bolster his squad by promoting players from the NextGen team, who play their football in Serie C, as he adds 21-year-old winger Sekulov.
So far this season, the Italy Under-20 international has scored four goals and provided two assists in 30 competitive matches for the Juventus NextGen team.
Juventus probable line-up: Szczesny; Gatti, Bremer, Danilo; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Di Maria; Vlahovic