Juventus are without Federico Chiesa and their South American players for the trip to Napoli, but Aaron Ramsey is back in the squad.
It kicks off on Saturday at 17.00 UK time (16.00 GMT).
The Bianconeri are decimated by injuries and absentees, as the late return from international duty forced them to leave behind the South American players such as Paulo Dybala, Juan Cuadrado, Alex Sandro, Danilo and Rodrigo Bentancur.
Chiesa picked up an injury while playing for Italy, joining Arthur Melo and Kaio Jorge on the treatment table.
Ramsey does return, but is unlikely to start, as he missed international duty with Wales due to yet another muscular issue.
Moise Kean is the favourite to play in a trident attack with Federico Bernardeschi and Alvaro Morata.
Mattia De Sciglio and Luca Pellegrini could be the full-backs, with Manuel Locatelli starting in midfield.
Juventus squad: Szczesny, Pinsoglio, Perin; De Sciglio, Chiellini, De Ligt, Pellegrini, Bonucci, Rugani, De Winter; Ramsey, McKennie, Bernardeschi, Rabiot, Locatelli, Kulusevski, Miretti; Morata, Kean, Soule