Daniele De Rossi has ‘great faith’ in his Roma players after big changes against Brighton in the Europa League Round of 16.
It kicks off at the Amex Stadium at 20.00 GMT.
You can follow all the build-up and action as it happens from this game, Atalanta-Sporting CP, Slavia Praha-Milan and Fiorentina-Maccabi Haifa on the LIVEBLOG.
Romelu Lukaku, Renato Sanches, Chris Smalling and Tammy Abraham are injured, with Paulo Dybala only fit for the bench.
It is an all-new trident attack of Tommaso Baldanzi, Sardar Azmoun and Nicola Zalewski.
“They train well together, have quality, so I am certain they will work well,” De Rossi told Sky Sport Italia.
“Besides, we need everyone to have a great game and work together, not just within the various sections of the team.”
Baldanzi was signed in January from Empoli and has barely featured so far, making this a huge opportunity to prove himself in the Roma jersey.
“Players need to be talented, it doesn’t matter how old they are, and these three are talented. We have great faith in those who are playing today, because they proved in training and when called upon that they deserve more playing time.
“They have nothing to prove here, they just need to play their game.”
The first leg was a 4-0 triumph for Roma, so it will take an extraordinary collapse for them to not reach the Europa League quarter-final.
“We believe in what we are doing. When there is pressure, you respond with good football. When there is pressing man on man, you respond with vertical passes.
“It’s going to be a great game in a spectacular stadium.”