Matthijs de Ligt pulled out in the warm-up for Juventus, so Gianluca Frabotta will replace him in the starting XI against Spezia.

It kicks off at 19.45 GMT, click here for the line-ups and LIVEBLOG.

De Ligt had been struggling with a tendon issue, but when he began the warm-up, he was visibly struggling.

After a conversation with coach Andrea Pirlo and fitness staff, the Dutchman walked into the dressing room shaking his head.

Matthijs de Ligt pulled out in the warm-up for Juventus, so Gianluca Frabotta will replace him in the starting XI against Spezia.

It kicks off at 19.45 GMT, click here for the line-ups and LIVEBLOG.

De Ligt had been struggling with a tendon issue, but when he began the warm-up, he was visibly struggling.

After a conversation with coach Andrea Pirlo and fitness staff, the Dutchman walked into the dressing room shaking his head.

Frabotta has started warming up in his place, a left-back, but can also play in central defence if needed.

It's possible Alex Sandro could move to the centre instead, leaving Frabotta on the left.

It’s a big problem for Juve, who are already missing Leonardo Bonucci, Giorgio Chiellini, Arthur, Juan Cuadrado and Paulo Dybala.

Juventus: Szczesny; Danilo, Demiral, Frabotta, Alex Sandro; Chiesa, Bentancur, Rabiot, McKennie; Kulusevski, Ronaldo

Juventus bench: Pinsoglio, Buffon, Ramsey, Morata, Bernardeschi, Di Pardo, Dragusin, Frabotta, Fagioli, Peeters, Ake

Spezia: Provedel; Vignali, Erlic, Terzi, Marchizza; Estevez, Sena, Maggiore; Farias, Nzola, Gyasi

Spezia bench: Zoet, Acampora, Ricci, Galabinov, Agoume, S Bastoni, Salva Ferrer, Chabot, Ismajli, Agudelo, Piccoli

Ref: Sacchi

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