Milan have Suso and Samu Castillejo flanking Krzysztof Piatek, while Lazio look to Joaquin Correa supporting Ciro Immobile in the Coppa Italia semi-final.
The first leg ended 0-0 and the decider kicks off at San Siro at 19.45 UK time (18.45 GMT), so away goals could prove crucial.
You can follow the build-up and action as it happens on the LIVEBLOG.
Milan have Suso and Samu Castillejo flanking Krzysztof Piatek, while Lazio look to Joaquin Correa supporting Ciro Immobile in the Coppa Italia semi-final.
The first leg ended 0-0 and the decider kicks off at San Siro at 19.45 UK time (18.45 GMT), so away goals could prove crucial.
You can follow the build-up and action as it happens on the LIVEBLOG.
These teams met only a few weeks ago in Serie A, with a brawl breaking out at the final whistle, Tiemoue Bakayoko and Franck Kessie investigated for unsporting conduct after waving Francesco Acerbi’s jersey at the home fans like a trophy and consequent racist abuse aimed at the two Milan players.
Lazio also protested over the refereeing decisions and implied the powers that be are favouring the Rossoneri for Champions League qualification.
Lucas Paqueta is still not fit enough to start, so Castillejo joins Suso and Coppa Italia top scorer Piatek in the trident attack of a new 3-4-3 formation.
Diego Laxalt steps in to the left wing with Davide Calabria on the right, Mattia Caldara coming in to the three-man defence for his first start in seven months.
Pepe Reina is once again the Coppa Italia choice in goal.
Lazio have Stefan Radu suspended, with Valon Berisha and Jordan Lukaku injured, but Correa gets the nod rather than Felipe Caicedo behind Immobile.
Sergej Milinkovic-Savic has a lot to prove, having been foolishly sent off at the weekend in a shock 2-1 home defeat to already-relegated Chievo.
The following players are one yellow card away from suspension: Ciro Immobile, Lucas Leiva, Adam Marusic, Sergej Milinkovic-Savic, Marco Parolo, Patric, Wallace, Davide Calabria, Gianluigi Donnarumma, Franck Kessie, Ricardo Rodriguez and Alessio Romagnoli.
The referee is Paolo Silvio Mazzoleni, the VAR is Piero Giacomelli.
Milan: Reina; Musacchio, Caldara, Romagnoli; Calabria, Kessie, Bakayoko, Laxalt; Suso, Piatek, Castillejo
Milan bench: G Donnarumma, A Donnarumma, Abate, Rodriguez, Conti, Zapata, Bertolacci, Biglia, Borini, Paquetà, Calhanoglu, Cutrone
Lazio: Strakosha; Luiz Felipe, Acerbi, Bastos; Romulo, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile
Lazio bench: Proto, Guerrieri, Wallace, Zitelli, Patric, Durmisi, Marusic, Jordao, Parolo, Badelj, Cataldi, Neto, Caicedo
Ref: Mazzoleni