Juventus look to Dejan Kulusevski and Alvaro Morata as a new strike partnership, with Matthijs de Ligt back in defence against Serie B side SPAL in this Coppa Italia quarter-final.
This tie will be decided after 90 minutes, extra time or even penalties.
It kicks off in Turin at 19.45 GMT, with the winners going on to face Inter in the semi-final.
Juventus look to Dejan Kulusevski and Alvaro Morata as a new strike partnership, with Matthijs de Ligt back in defence against Serie B side SPAL in this Coppa Italia quarter-final.
This tie will be decided after 90 minutes, extra time or even penalties.
It kicks off in Turin at 19.45 GMT, with the winners going on to face Inter in the semi-final.
You can follow all the action as it happens and give your views on the LIVEBLOG.
Andrea Pirlo won his first trophy as a coach in last week’s Supercoppa Italiana victory over Napoli, following it up with a Serie A win against Bologna.
The Bianconeri have shown a tendency to slip up with the wrong approach against smaller clubs this season, so facing the only remaining Serie B side in the Coppa Italia brings risks.
Paulo Dybala is on the treatment table, but De Ligt returns to the starting XI for the first time since his COVID diagnosis.
Alex Sandro has also been given the all-clear from the virus, but only resumed training this morning.
Pirlo gives a senior squad debut to teenage midfielder Nicolò Fagioli, while Radu Dragusin gets the nod in defence.
Cristiano Ronaldo is rested, so Morata partners Kulusevski in a new front pairing.
For all the youth in the side, Juventus also start Gigi Buffon the day before his 43rd birthday.
SPAL knocked out Monza, Crotone and Sassuolo on their way to the quarter-finals for the first time since 1981, but miss Federico Di Francesco, Marco D’Alessandro and suspended Marco Tumminello.
Veteran Sergio Floccari starts upfront, with Lorenzo Dickmann and Demba Seck providing pace down the wings.
Juventus: Buffon; Dragusin, De Ligt, Demiral, Frabotta; Bernardeschi, Fagioli, Rabiot, Ramsey; Kulusevski, Morata
Juventus bench: Szczesny, Pinsoglio, Chiellini, Alex Sandro, Danilo, Cuadrado, Bonucci, Di Pardo, Arthur, McKennie, Chiesa, Da Graca
SPAL: Berisha; Ranieri, Vicari, Okoli; Dickmann, Esposito, Missiroli, Sernicola; Brignola, Seck; Floccari
SPAL bench: Thiam, Minelli, Tomovic, Valoti, Paloschi, Viviani, Spaltro, Strefezza, Sala, Moro
Ref: Pezzuto