Napoli coach Walter Mazzarri is expected to rotate massively in a Coppa Italia Round of 16 tie against Frosinone, starting Jesper Lindstrøm, Giovanni Simeone and Giacomo Raspadori in attack.
It kicks off at 20:00 GMT at the Stadio Maradona in Naples and the winner will face Salernitana or Juventus in the quarter-finals.
The Partenopei are without André Zambo Anguissa, Mathias Olivera and Eljif Elmas, but most regular starters, including Victor Osimhen and Khvicha Kvaratskhelia, will rest. Gianluca Gaetano and Jens Cajuste are expected to start in central midfield. Alessandro Zanoli is favourite over Giovanni Di Lorenzo as a right-back.
Frosinone will also rotate. They have travelled to Naples without the injured Riccardo Marchizza, Luca Mazzitelli, Anthony Oyono, Reinier and Sergio Kalaj.
Abdou Harroui is expected to return to the starting XI for the first time in over two months. Luca Garritano will likely start as a left-back, while Napoli-owned striker Walid Cheddira will get the nod in attack after remaining on the bench in the last three Serie A matches.
Napoli-Frosinone: probable line-ups
Napoli (4-3-3): Gollini; Zanoli, Ostigard, Natan, Mario Rui; Cajuste, Lobotka, Gaetano; Raspadori, Simeone, Lindstrom.
Frosinone (4-3-3): Cerofolini; Lirola, Okoli, Romagnoli, Garritano; Barrenechea, Bourabia, Harroui; Baez, Cheddira, Caso.