Roma field practically a full-strength squad with Sergio Oliveira, Tammy Abraham and Ainsley Maitland-Niles in the Coppa Italia Round of 16 against Lecce.
It kicks off at the Stadio Olimpico at 20.00 GMT.
The winners will be decided after 90 minutes, extra time or even penalties if required.
Whoever gets through will face Inter in the quarter-final next month.
So many of the Round of 16 fixtures have gone to extra time, that Jose Mourinho doesn’t want to take any chances and is using almost a full-strength side.
Gianluca Mancini is suspended, with Lorenzo Pellegrini and Leonardo Spinazzola injured, Chris Smalling has COVID-19, while Amadou Diawara and Ebrima Darboe are at the Africa Cup of Nations.
Lecce are the only remaining Serie B side still in the Coppa Italia and they go into this game without hitman Pablo Rodriguez due to a muscular problem, joining Alessandro Tuia, Luca Paganini and Fabio Pisacane on the absentee list.
Roma: Rui Patricio; Karsdorp, Ibanez, Kumbulla, Maitland-Niles; Cristante, Veretout; Carles Perez, Sergio Oliveira, Felix; Abraham
Lecce: Bleve; Gendrey, Calabresi, Dermaku, Barreca; Blin, Listkowski, Helgason; Gargiulo, Di Mariano, Olivieri