Juventus opt for a 4-4-2 with Dusan Vlahovic, Paulo Dybala and Denis Zakaria in the Coppa Italia quarter-final against Giacomo Raspadori and Gianluca Scamacca’s Sassuolo.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
Coppa Italia Liveblog: Atalanta-Fiorentina and Juventus-Sassuolo
The tie must be decided tonight after 90 minutes, extra time or even penalties if necessary.
The winners go on to face either Atalanta or Fiorentina in the two-legged semi-final.
Juventus are the Coppa Italia holders and go into this clash with their new star striker Vlahovic, who with Denis Zakaria already scored on his Bianconeri debut at the weekend.
This time, Alvaro Morata is sent to the bench, as Juan Cuadrado becomes a winger in the 4-4-2, with Dybala and Vlahovic upfront.
Leonardo Bonucci returns after five weeks out, as Giorgio Chiellini and Federico Bernardeschi are injured, with Moise Kean suspended.
Sassuolo have Matheus Henrique back after a muscular injury, while they are practically forced to use their first-choice attack.
This is because both Scamacca and Raspadori are suspended this weekend in Serie A, so there’s no need for them to rest, and Domenico Berardi completes the attack.
Juventus: Perin; De Sciglio, Bonucci, De Ligt, Alex Sandro; Cuadrado, Zakaria, Arthur, McKennie; Vlahovic, Dybala
Sassuolo: Pegolo; Tressoldi, Ayhan, Ferrari, Kyriakopoulos; Harroui, Lopez; Berardi, Raspadori, Traore; Scamacca