Roma look to Andrea Belotti and Stephan El Shaarawy in the Coppa Italia quarter-final against giant-killers Cremonese, who already eliminated Napoli and here start ex-Giallorossi striker Felix Afena-Gyan.
It kicks off at the Stadio Olimpico at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Fiorentina-Torino on the LIVEBLOG.
The Giallorossi had a traumatic January transfer window, which resulted in Nicolò Zaniolo and Rick Karsdorp being frozen out.
Leonardo Spinazzola picked up a muscular injury, joining Georginio Wijnaldum in the stands, while Tammy Abraham is rested in favour of Belotti.
Cremonese shocked Napoli on penalties after a 2-2 thriller in the Coppa Italia Round of 16, which was the debut of new coach Davide Ballardini.
He followed that up with a 1-1 draw at Bologna and narrow 2-1 defeat to Inter.
New signing Pablo Galdames is on the bench and Charles Pickel returns from a Serie A ban, but all eyes are on ex-Roma youth product Felix Afena-Gyan.
Jose Mourinho famously bought the 20-year-old a pair of sneakers to reward him for his debut Serie A goal.
Leonardo Sernicola is suspended, with Giacomo Quagliata, Cristian Buonaiuto and Luka Lochosvhili injured.
The winners will face Fiorentina in the two-legged semi-final in April.
Roma: Rui Patricio; Mancini, Kumbulla, Ibanez; Celik, Tahirovic, Cristante, Pellegrini; El Shaarawy, Volpato; Belotti
Cremonese: Sarr; Ferrari, Aiwu, Bianchetti; Ghiglione, Pickel, Castagnetti, Meité, Tsadjout, Dessers, Afena-Gyan